| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_164e382c7353e3859fad6a6cd8f2ef03 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1353 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775 |
| filingDate |
2012-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b394713d94b336aa4ba541a321e1ee9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aecba5d764cabc89943c8543972c4995
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4729ff05faf32ae7a97117427ac23720 |
| publicationDate |
2014-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2440371-A1 |
| titleOfInvention |
Cells, cell lines and non-human animal model, for the determination of therapeutic agents. |
| abstract |
Cells, cell lines and non-human animal model, for the determination of therapeutic agents. # The present invention describes isolated mesenchymal stem cells differentiated to osteogenic progenitor, genetically modified by deleting the sequences or a fragment of the sequences encoding the p53 protein and Rb protein. The cells described in the present invention also have the ability to cause tumors in vivo of the osteosarcoma type. In the present invention cell lines and populations are also described, as well as a non-human animal model to which said osteosarcoma-like stem cells have been implanted. Similarly, the present invention describes the method of obtaining said cells and uses, preferably for screening agents useful in the treatment and / or prevention of sarcoma. |
| priorityDate |
2012-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |