http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2439454-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 2006-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f86f44f34372ee3747f3faed922046b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_081ec3d0e20ac7d2d93e2b43ad9ebb60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34e0cceeb6772e7a04bbcd17b6940aca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_920f8a6a637b00f88af322d3e9787969 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46ba4f72cf04165ea83d21c940de768f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b253e979481cd796670f1219cbfdf0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55eaddafa8305602336d5ea2c136f735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2afffdb9dca2d8071d68b28627d7e569 |
| publicationDate | 2014-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2439454-T3 |
| titleOfInvention | Diaminopyrimidines as modulators of P2X3 and P2X2 / 3 |
| abstract | The use of a compound of formula I or a pharmaceutically acceptable salt thereof, wherein: X is -CH2 -; - O-; or -CHOH-; And it is hydrogen; or -NRdRe in which Rd and Re is hydrogen, and the other is hydrogen; I rent; cycloalkyl; cycloalkylalkyl; haloalkyl; haloalkoxy; hydroxyalkyl; alkoxyalkyl; acetyl; alkylsulfonyl; alkylsulfonylalkyl; aminocarbonyloxyalkyl; hydroxycarbonylalkyl; hydroxyalkyloxycarbonylalkyl; aryl; aralkyl; arylsulfonyl; heteroaryl; heteroarylalkyl; heteroarylsulfonyl; heterocyclyl; or heterocyclylalkyl; D is an optional oxygen; R1 is alkyl; alkenyl; cycloalkyl; cycloalkenyl; halo; haloalkyl; hydroxyalkyl; or alkoxy; R2, R3, R4 and R5 each independently is hydrogen; I rent; alkenyl; Not me; halo; amido; haloalkyl; alkoxy; hydroxy; haloalkoxy; nitro; hydroxyalkyl; alkoxyalkyl; hydroxyalkoxy; alkylalkoxy; alkylsulfonyl; arylsulfonyl; cyano; aryl; heteroaryl; heterocyclyl; heterocyclylalkoxy; aryloxy; heteroaryloxy; aralkyloxy; heteroaralkyloxy; optionally substituted phenoxy ;-( CH2) m- (Z) n- (CO) -Rf or - (CH2) m- (Z) n-SO2- (NRg) n-Rf in which myn each of them independently are 0 or 1, Z is O or NRg, Rf is hydrogen, alkyl, hydroxy, alkoxy, amino, hydroxyalkyl or alkoxyalkyl, and each Rg is independently hydrogen or alkyl; R6 is hydrogen; I rent; halo; haloalkyl; Not me; or alkoxy; and one of R7 and R8 is hydrogen, and the other is hydrogen; I rent; cycloalkyl; cycloalkylalkyl; haloalkyl; haloalkoxy; hydroxyalkyl; alkoxyalkyl; acetyl; alkylsulfonyl; alkylsulfonylalkyl; aminocarbonyloxyalkyl; hydroxycarbonylalkyl; hydroxyalkyloxycarbonylalkyl; aryl; aralkyl; arylsulfonyl; heteroaryl; heteroarylalkyl; heteroarylsulfonyl; heterocyclyl; or heterocyclylalkyl. for the preparation of a medicament for the treatment of a P2X3 or P2X2 / 3 receptor-mediated respiratory disease, wherein said disease is a respiratory disease selected from chronic obstructive pulmonary disease (COPD), asthma and bronchospasm. |
| priorityDate | 2005-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1312.