http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2439042-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c10f43b8b2e4032e99c412259d95a746 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2010-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac84f5677eeff927a2fff02b17eccc45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc22c30088175ed08634c15e93a248ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a05bb348c3d1faead66a81651539b8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ac2575a699e439d41a21cc097c99b67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ae59fbf61bc4d9a199c6b404aa026b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a34f7858302ba8d90fa0cc96272a1bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b8533586688c1350d5de5fc6ac6ca7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99f0b38a6054ccaaf0752e13c0242d18 |
| publicationDate | 2014-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2439042-T3 |
| titleOfInvention | 5,6,7,8-tetrahydroimidazo [1,2-a] pyrazine derivatives as modulators of P2X7 |
| abstract | A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, (C1-3alkoxy) - (C1-4alkyl) , C1-2 fluoroalkyl, halogen, NR6R7, Het, or phenyl wherein phenyl is optionally substituted with 1, 2, or 3 substituents that are independently fluoro, chloro, C1-3 alkyl, OH, methoxy, or deuterium; where Het is: i) a 6-membered heteroaromatic monocyclic ring containing 1, 2 or 3 nitrogen atoms in the ring, or ii) a 5-membered heteroaromatic monocyclic ring containing 1, 2 or 3 heteroatoms in the ring that are independently N, O, or S, wherein no more than one of the heteroatoms in the 5-membered ring O or S; iii) a 9 or 10 membered heteroaromatic bicyclic ring containing 1, 2 or 3 nitrogen atoms in the ring; and wherein Het is optionally substituted with 1 or 2 substituents that are independently C1-3alkyl, fluoro, chloro, OH including a tautomer thereof, methoxy or deuterium; and where: R1 is hydrogen, chlorine, fluorine, bromine, C1 fluoroalkyl, cyano or C1-3alkyl; R2 is hydrogen, fluorine, chlorine, bromine, C1 fluoroalkyl, cyano, or C1-3 alkyl; R3 is hydrogen, fluoro, chloro or C1-3 alkyl, R4 is hydrogen; R5 is hydrogen, fluorine, chlorine, or methyl; R6 and R7 are independently hydrogen or C1-3alkyl; or R6 and R7 are considered together and are - (CH2) 2-O- (CH2) 2-, - (CH2) 2-O- (CH2) 3-, or - (CH2) n1- where n1 is 3, 4, 5 or 6; and R14 is hydrogen, C1-6alkyl, fluoro C1-2alkyl, C3-6cycloalkyl, halogen, or phenyl wherein phenyl is optionally substituted with 1 or 2 substituents which are independently fluoro, chloro, methyl, -CF3 or methoxy; where, when A is hydrogen, C1-4alkyl, or C1-3alkyl, C1-3alkoxy, (C1-3alkoxy) - (C1-4alkyl), fluoroC1-2alkyl, halogen, or NR6R7, then R1 is chlorine , fluorine, bromine, C1 fluoroalkyl, cyano or C1-3alkyl, and at least one of R2 and R3 is other than hydrogen; and when A is Het or optionally substituted phenyl, then R1 is hydrogen, chlorine, fluorine, bromine, C1 fluoroalkyl, cyano or C1-3alkyl, at least one of R1, R2 and R3 is other than hydrogen, and R14 is hydrogen, C1-6alkyl, fluoro C1-2alkyl, C3-6cycloalkyl or halogen; ~ and where, when R5 is fluoro, chloro or methyl, then R1 is chloro, fluoro, C1 fluoroalkyl or methyl and R2 is hydrogen. |
| priorityDate | 2009-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 558.