| abstract |
Proapoptotic polypeptide containing α helix for use in the treatment of cancer or neoplastic diseases, said polypeptide of formula (III) being: in which; each R1 and R2 are independently H, C1-C20 alkyl, C2-C20 alkenyl, C2-10 C20 alkynyl, arylalkyl, cycloalkylalkyl; heteroarylalkyl or heterocyclylalkyl; each n is independently an integer from 1 to 15; x is 2, 3 or 6; each y is independently an integer from 0 to 100; z is an integer from 1 to 10; and each Xaa is independently an alpha-amino acid and is the same amino acid as in the proapoptotic polypeptide that contains α helix. |