http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2437147-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcb35225a578542c5592310a91d18f18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 |
| filingDate | 2009-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efe730cae3c2da3fccee04e8491d8515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3a5496bd46c2815da93474a71a4454e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca0a0247f20e584938acb55316c133f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32c978b166950946343cf546cbeb589d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0f1e09364b03c8264ceb9073ab283e8 |
| publicationDate | 2014-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2437147-T3 |
| titleOfInvention | Macrocyclic serine protease inhibitors |
| abstract | A compound of formula 1: or a single enantiomer, a racemic mixture, or a mixture of diastereoisomers thereof; or a pharmaceutically acceptable osolvate salt thereof; where: R5 is -OH, -NR8R9, -NHS (O) 2R8, -NHS (O) 2NR8R9, -NHC (O) R8, -NHC (O) NR8R9, -C (O) R9, or -C ( O) NR8R9; where: each R8 is independently hydrogen C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C6-4aryl, heteroaryl, heterocyclyl, (C1-6alkyl) - (C3-7cycloalkylene) , -CH2NR8aR8b, -CH (R8c) NR8aR8b, -CHR8cCHR8dNR8aR8b, or -CH2CR8cR8dR8aR8b, where: each R8a, R8c, and R8d is independently hydrogen, C1-6alkyl, C2alkyl, C3alkyl 7, C6-4 aryl, heteroaryl, heterocyclyl, or (C6-14 aryl) - (C1-6 alkylene); and each R8b is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-4 aryl, heteroaryl, heterocyclyl, -S (O) kR11, -S (O) kNR11R12, -C (O) R11, -C (O) OR11, -C (O) NR11R12, or -C (> = NR13) NR11R12; Wherein each R11, R12, and R13 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-4 aryl, heteroaryl, or heterocyclyl; or R11 and R12 together with the N atom to which they are attached form heterocyclyl; or R8a and R8b together with the N atom to which they are attached form heterocyclyl; and each R9 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-4 aryl, heteroaryl, or heterocyclyl; or R8 and R9 together with the N atom to which they are attached form heterocyclyl; R6 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-4 aryl, heteroaryl, or heterocyclyl; L is a bond, C1-6 alkylene, C3-7 cycloalkylene, alkenylene C2-6, C2-6 alkynylene, X, or - (CR6aR6b) pX-; where you weigh an integer 1, 2, or 3; R6a and R6b are each independently hydrogen, halogen, cyano, hydroxyl, or alkoxy; and X is -O-, -C (O) -, -C (O) O-, -OC (O) O-, -C (O) NR14-, -NR14-, -NR14C (O) NR15-, -C (> = NR14) NR15 -, - NR14C (> = NR15) NR16-, -S (O) k-, -S (O) kNR14-, -NR14S (O) kNR15-, -P (O) ( OR14) -, or -OP (O) (OR14) -, where each R14, R15 and R16 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-4 aryl, heteroaryl, or heterocyclyl; and each k is independently an integer 1 or 2; Q1 is -O-, -N (R7) -, -C (R18R19) -, or -CR17 (NR18R19) -; wherein: each R17 and R18 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-4 aryl, heteroaryl, or heterocyclyl; and each R19 is independently -R20, -C (O) R20, -C (O) OR20, -C (O) NR21R22, -C (> = NR20) NR21R22, or -S (O) kR20; where each R20, R21 and R22 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-4 aryl, heteroaryl or heterocyclyl; or R21 and R22 together with the N atom to which they are attached form heterocyclyl; oR18 and R19 together with the C or N atom to which they are attached form C3-7 cycloalkyl or heterocyclyl. |
| priorityDate | 2008-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1603.