| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb7ce8745175865c6357f7d5fe7fccf5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 |
| filingDate |
2009-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b116dc03a12ae3824975f5be3431a93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28bcb8f7c0af95b2b1cc4ce5fec573b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_413bc89a2ed384f3344d70a5c3026cc0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1d3c8aba93448d775f0591d86a81def
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83e0d9ad7a47ec21f7d6fac990ba18fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c189950daf812efdfaaa18c1498d62de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78d4f662c794a67f6fe46939bb1b788c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0973390f044fc323930e5d165d4a3267
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fb8696b951d1277adf7fa2cb6ae6265
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_982b30a129674c0db7cda7fd828d23dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c10d4d7416f2674ca857a6dffccf56e6 |
| publicationDate |
2014-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2436662-T3 |
| titleOfInvention |
Preparation procedures for polymorphic form A of bazedoxifene acetate |
| abstract |
A process for preparing polymorphic form A of bazedoxifene acetate, the procedure comprising: (a) contacting 1- (4- (2-azepan-1-yl) ethoxy) benzyl) -5- (benzyloxy) -2- (4- (benzyloxy) phenyl) -3-methyl-1H-indole with hydrogen in a solvent comprising ethanol and in the presence of a catalyst at elevated temperature to provide a first reaction mixture comprising bazedoxifene free base, in which less 1% of 1- (4- (2-azepan-1-yl) ethoxy) benzyl) -5- (benzyloxy) -2- (4- (benzyloxy) phenyl) -3-methyl-1H-indole remains in the reaction mixture; (b) treating said first reaction mixture with an antioxidant, to provide a second reaction mixture; (c) filtering said second reaction mixture, to provide a solution comprising free base debazedoxifene; and (d) treating said solution with acetic acid, to crystallize Form A of bazedoxifene acetate in which the elevated temperature in step (a) is a temperature of 40 ° C to 60 ° C. |
| priorityDate |
2008-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |