| abstract |
a compound of the formula I: ** Formula ** wherein, a, is a number from 0 to 5; each R1 is independently selected from halo, -C1-6 alkyl, -C2-6 alkynyl, -O-C1-6 alkyl, -C 1-4 alkylene-O-C1-4 alkyl, -C0 alkylene -1-phenyl, -O-C0-3-phenyl, -C0-6- OH, -CN, -C0-2-COOH, -CHO, -C (O) -C1-6 alkyl, -C (O) O-C1-4 alkyl, -CH2SH, -S-C1-6 alkyl, -C1-4 alkyl-S-C1-4 alkyl, -SO2-C1-4 alkyl, -SO2NRaRb, -NHSO2Ra, -alkylene C0-1- NRaRb, -NHC (O) -C1-6 alkyl, -C (O) NRaRb, and -NO2; R2 to R6, are independently selected from H, halo, -C 1-6 alkyl , -C2-6alkynyl, -O-C1-6alkyl, -C1-4alkyl-O-C1-4alkyl, -C0-1 -alkyl-phenyl, -O-C0-3 -phenyl, -C0 -alkylene 6-OH, -CN, -C0-2-COOH, -CHO, -C (O) -C1-6 alkyl, -C (O) O-C1-4 alkyl, -CH2SH, -S-C1-alkyl 6, -C1-4-S-C1-4-alkyl, -SO2-C1-6 alkyl, -SO2NRaRb, -NHSO2Ra, -C0-1-NRaRb, -NHC (O) -C1-6 alkyl, -C (O) NRaRb, and -NO2; Ra and Rb are, independently of each other with respect to each other, H or C1-4 alkyl; each alkyl, in R1 to R6, is optionally substituted with 1 to 5 fluorine atoms; and each phenyl, in R1 to R6, is optionally substituted with 1 or 2 groups independently selected from halo, C1-6 alkyl and -O-C1-6 alkyl; or a pharmaceutically acceptable salt thereof. |