| abstract |
A benzoyl compound represented by the general formula (I): ** Formula ** where n represents an integer from 1 to 5; R1 represents a substituted or unsubstituted C1.8 alkyl, substituted or unsubstituted C1.8 alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted (C1.8 alkoxy) carbonyl, a substituted or unsubstituted, arylsubstituted or unsubstituted heterocyclic alkyl. , CONR7R8 (where R7 and R8 independently represent a hydrogen atom, substituted or unsubstituted C1.8alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted C1.7 alkanoyl, arylsubstituted or unsubstituted, a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aralkyl, substituted or unsubstituted alkylheterocyclic, or substituted or unsubstituted aroyl, or R7 and R8 form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or NR9R10 (where R9 and R10 have the same meanings as R7 and R8 above, respectively); R2 represents substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group; R3 R4 and R5, each represents a hydrogen atom; and R6 represents halogen, or C1.8 alkyl, and where (i) the substituents on substituted C1.8-alkyl, substituted C1.8-alkoxy and substituted (C1.8-alkoxy) carbonyl were 1 to 3 substituents that are the same or different, selected from group (A) consisting of hydroxy, oxo, cyano, nitro, carboxy, amino, halogen, substituted or unsubstituted C1.8 alkoxy, cycloalkyl, C1.7 alkanoyl, (C1.8 alkoxy) carbonyl, C1.8alkylamino, and di (C1.8alkyl) amino, where the substituents on said C1 alkoxy .8 substituted are 1 to 3 substituents that are the same or different, selected from the group consisting of hydrogen and halogen and (ii) the substituents on the substituted cycloalkyl, the substituted heterocyclic alkyl, the substituted aryl, the substituted C1.7 alkanoyl, the group substituted heterocyclic, substituted aralkyl, the substituted aroyl and the substituted heterocyclic group formed together with the adjacent nitrogen atom are between 1 to 3 substituents that are the same or different, selected from group (B) consisting of hydroxy, halogen, nitro, cyano, amino, carboxy, carbamoyl, alkyl Substituted or unsubstituted C1.8, substituted or unsubstituted C1.8 alkoxy, aralkyloxy, C1.8-alkyl sulfonyl, C1.8-alkyl-sulfanyl, cycloalkyl, (C1.8-alkoxy) carbonyl, C1.8-alkyl, di (C1-alkyl. 8) amino, C1.7 alkanoyl, a heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic alkyloxy, and substituted or unsubstituted carbonylalkyl alkoxyheterocyclic, wherein the substituents on said substituted C1.8 alkyl, said substituted C1.8 alkoxy and said Substituted aryl are 1 to 3 same or different substituents selected from the group consisting of hydroxy, halogen, C1.8 alkoxy, cyano, C1.8alkyl amino and di (C1.8alkyl) amino, and substituents on said alkyloxyhetero substituted cyclic and said substituted heterocyclic carbonylalkyloxy are 1 to 3 substituents that are the same or different, selected from the group consisting of hydroxy, halogen, C1.8alkyl, C1.8alkoxy, and a pharmaceutically acceptable salt thereof. |