| abstract |
A composition comprising an RNAi agent that contains a sense chain and an antisense chain, wherein: a. the sense chain comprises at least 19 contiguous nucleotides of the sense chain of ND8453 (SEQ ID NO: 1425), and the antisense chain comprises at least 19 contiguous nucleotides of the antisense chain of ND8453 (SEQ m NO: 1426), or b. the sense chain comprises at least 19 contiguous nucleotides of the sense chain of ND8489 (SEQ ID NO: 1497), and the antisense chain comprises at least 19 contiguous nucleotides of the antisense chain of ND8489 (SEQ m NO: 1498); or c. the sense chain comprises at least 19 contiguous nucleotides of the sense chain of ND8456 (SEQ ID NO: 1431), and the antisense chain comprises at least 19 nucleotides of the antisense chain of ND8456 (SEQ IDNO: 1432). |