| abstract |
An alpha-helical polypeptide of the formula: ** Formula ** or a pharmaceutically acceptable salt thereof; in which: each case of L1 and L2 is independently a straight chain alkylene of 3 to 7 carbon atoms; each case of K and M is, independently, a straight chain alkylene of 1 to 7 carbon atoms; each case of Ra is hydrogen or alkyl of 1 to 6 carbon atoms or acyl, such as COCH3; each case of Rb is hydrogen or cyclic or acyclic aliphatic, branched or unbranched, substituted or substituted; each case of Re is, independently, -RE, -ORE, -N (RE) 2, or -SRE, in which each case of RE is, independently, hydrogen, cyclic or acyclic aliphatic, branched or unbranched, substituted or replaced us; heteroaliphatic cyclic or acyclic, branched or unbranched, substituted or unsubstituted; arylsubstituted or unsubstituted; substituted or unsubstituted heteroaryl; substituted or unsubstituted acyl; a resin; a suitable hydroxyl, amino or thiol protecting group; or two RE groups together form a substituted or unsubstituted 5- or 6-membered heterocyclic heterocyclic ring. |