http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2428716-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2009-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b5ce6af00899c64f688384b241ad700 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_037e59f9554c70ff97c56559eee6d3ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f159f23260a4cb3774363aea583b37b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f69daf39ce0da364a70bb1bba8f7c4dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45590828fce09c7cdec31e2339d1a132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01d467c8ab43b6003a42cf8de7b47771 |
| publicationDate | 2013-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2428716-T3 |
| titleOfInvention | Beta-amyloid modulators |
| abstract | A compound of general formula I-A-1 in which R2 is hydrogen, C1-C7 alkoxy, C1-C7 alkyl, cyano or halogen; R3 is C1-C7 alkyl, C2-C7 alkenyl, C1-C7 alkyl substituted by fluorine, (CH2) 2O-C1-C7 alkyl, (CH2) 2NR82, or is 4H-benzo [1,4] oxazin-3-one , cycloalkyl optionally substituted by hydroxy, or is heterocycloalkyl, said heterocycloalkyl is optionally substituted by hydroxy or S (O) 2-C1-C7 alkyl, or is (CH2) 0.1-aryl or esoxazol-5-yl, [1,2 , 4] triazol-1-yl, 1,2,4] triazol-3-yl, [1,2,3] triazol-1-yl, imidazol-1-yl, furan-2-yl, thiophene-2- ilo, pyrazol-4-yl, pyrazol-3-yl, pyrazol-1-yl, [1,2,4] -oxadiazol-5-yl, [1,3,4] -oxyadiazol-2-yl, or [ 1,2,4] thiadiazol-5-yl-rings are optionally substituted by one or more R 'for any definition of L, oes halogen, hydroxy, -C (O) O-C1-C7 alkyl, OC (O) -alkyl C1-C7 or C (O) NH2 being for L a bond, or is C1-C7 alkoxy, hydroxy, -C (O) O-C1-C7 alkyl, OC (O) -C1-C7 alkyl or C (O) NH2 being for L -CR6R7-, o is C1-C7 alkoxy, hydroxy or NR8 2 being for LC (O); R 'is halogen, C1-C7 alkyl, C1-C7 alkoxy, cyano, fluorine substituted C1-C7 alkyl, fluorine substituted C1-C7 alkoxy, SF5, or is a five-link heteroaryl group, which may optionally be substituted by C1-alkyl -C7; Ar is a five-link heteroaryl group or is pyridinyl; Z is CH or N; R4, R5 independently of one another are hydrogen, halogen, C1-C7 alkyl, C1-C7 alkoxy, C (O) O-C1-C7 alkyl, C1-C7 alkyl substituted by one or more groups chosen from fluorine, hydroxy, cyano or cycloalkyl, or are cyano, phenyl, benzyl or a heteroaryl group of five or six links, said rings are optionally substituted by one or more R ', or are cycloalkyl or heterocycloalkyl, which are optionally substituted by C1- alkyl C7e hydroxy, and with the proviso that R4 can be hydroxy or NR8 2; and wherein R4 and R5 can form together with the corresponding carbon atoms to which an additional ring is attached with - (CH2) 3,4; L is a bond, -CR6R7-, -O-, or -C (O) -; R6, R7 independently of each other are hydrogen, C1-C7 alkyl, cycloalkyl, phenyl or R6 and R7 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, and with the proviso that R6 can also be hydroxy or C1-C7 alkoxy; R8 is hydrogen or C1-C7 alkyl; or to a pharmaceutically active acid addition salt thereof. |
| priorityDate | 2008-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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