| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b1f830168bfc5ed125b9ae92679d425 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-20 |
| filingDate |
2011-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5301d1e0c3fbb0856dfd9fe69934f1db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0131798f8ccd6e425395c99ba2ae4c02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_968fc86b4d2e1f048796b120a5caf585 |
| publicationDate |
2013-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2428439-T1 |
| titleOfInvention |
A procedure for the preparation of Ramipril |
| abstract |
A process for the enantiospecific synthesis of (2S) -acetylamino-3- (2-oxocyclopentyl) propionic acid of formula (I) optically pure comprising: ** Formula ** hydrolyzing a stereoisomeric mixture of 2- (acetylamino) -3- ( C1-4alkyl 2-oxocyclopentyl) propanoate of formula (II), wherein R is C1-4alkyl, ** Formula ** with an alkaline endopeptidase serine enzyme, forming a mixture of the (+) acid (2S) isomer -acetylamino-3- (2-oxocyclopentyl) propionic (I) and isomer (-) (2R) -2- (acetylamino) -3- (2-oxocyclopentyl) C1-4 (III) alkyl propanoate ** Formula * * |
| priorityDate |
2010-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |