abstract |
A compound of formula I ** Formula **, or a pharmaceutically acceptable salt thereof. wherein ring A is heterocyclyl; wherein ring A is optionally substituted with one or more substituents selected from the group consisting of halo, carboxy, cyano, oxo, aryl, heterocyclyl, (C1-C8) alkyl, -OP (O) (R10) n, - OR11, -OC (O) R12, -C (O) OR12, -C (O) R13, - C (O) NR14R15, -NR16R17, -N (R18) C (O) R19, -N (R18) S (O) 2R19, -SO2R20 and -SO2NR21R22; wherein (C1-C8) alkyl is optionally substituted with one or more substituents selected from the group consisting of halo, cyano, aryl, heterocyclyl, -OR23, -OC (O) R24, -NR25R26, -C (O) NR27R28, -SR29, -SO2R30, -SO2NR31R32, -N (R33) C (O) R34 and - N (R35) S (O) 2R36; R10 is selected from the group consisting of hydroxy and (C1-C6) alkoxy; n is one or two; R11 is selected from the group consisting of hydrogen, (C1-C6) alkyl, hydroxy (C1-C6) alkyl, aryl, alkylaminocarbonyl (C1-C6) (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkyl ), (C1-C6) alkoxycarbonyl (C1-C6) alkyl, halo (C1-C6) alkyl (C1-C6) alkyl, heterocyclylcarbonylalkyl (C1-C6) and aminocarbonylalkyl (C1-C6) alkyl; R12, R13, R14, R15, R16, R17, R18, R21, R22, R24, R25, R26, R27, R28, R31, R32, R33, R34, R35 and R36 are independently selected from the group consisting of hydrogen and alkyl (C1-C6). |