abstract |
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein: n is 0 or 1; X is CH2, C> = O or C> = S; R1 is: a) - (CH2) mR3 or -CO (CH2) mR3, where m is 0, 1, 2 or 3; and R3 is 5-10 membered aryl or heteroaryl, optionally substituted with one or more halogens; b) -C> = YR4, where Y is O or S; and R4 is: (C0-C10) alkyl - (5-10 membered heteroaryl or heterocycle), said heteroaryl or heterocycle optionally substituted with one or more of (C1-C6) alkyl, halogen, oxo, (C1-C6) alkoxy , or -Z-(C1-C6) alkyl, wherein Z is S or SO2, and wherein said (C1-C6) alkyl may be optionally substituted with one or more halogens; or (C0-C6) alkyl (5 to 10 membered aryl), said aryl optionally substituted with one or more of: halogen; (C1-C6) alkoxy, itself optionally substituted with one or more halogens; (C1-C6) alkyl, itself optionally substituted with one or more halogens; or -Z-(C1-C6) alkyl, wherein Z is S or SO2, and wherein said (C1-C6) alkyl may be optionally substituted with one or more halogens; or c) -C> = ZNHR6, where Z is O or S; and R6 is 5-10 membered aryl or heteroaryl, optionally substituted with one or more of: halogen; cyano; (C1-C6) alkylenedioxy; (C1-C6) alkoxy, itself optionally substituted with one or more halogens; (C1-C6) alkyl, itself optionally substituted with one or more halogens; or (C1-C6) alkylthio itself optionally substituted with one or more halogens; and R2 is H or (C1-C6) alkyl. |