http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2424340-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fed2b7de0f46aff7b08dd465a2841e2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-429 |
| filingDate | 2010-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_494e63d168d3e4194ad21f2c47ff349a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fabc7124c451d747ab3cc47c6f7d047e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9c4047b54b615e7b35be7e3e8cc2ee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae155d4e9e532803a5ca6cfe4dca77f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9abc66731f1f5baefdf12ff66f514919 |
| publicationDate | 2013-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2424340-T3 |
| titleOfInvention | Isothiazole-pyrimidinedione derivatives as modulators of TRPA1 |
| abstract | The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, in which Y and Z are independently selected from sulfur or nitrogen, with the proviso that Y and Z are not simultaneously identical; R1 and R2, which may be the same or different, are independently selected from hydrogen, hydroxyl, unsubstituted or substituted alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, arylalkyl, (CRxRy) nORx, CORx, COORx, CONRxRy, (CH2) nNRxRy, (CH2) nCHRxRy and (CH2) nNHCORx; R3 is selected from hydrogen, substituted or unsubstituted alkyl, alkenyl, haloalkyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl; L is a linker chosen from - (CRxRy) n -, -O- (CRxRy) n-, -C (O) -, -NRx -, -S (O) mNRx -, - NRx (CRxRy) n- and - S (O) mNRx (CRxRy) n; U is chosen from substituted or unsubstituted aryl, substituted or unsubstituted five-membered heterocycles chosen from thiazol, isothiazole, oxazol, isoxazole, thiadiazole, oxadiazole, pyrazole, imidazole, furan, thiophene, pyrroles, 1,2,3-triazoles and 1, 2,4-triazole, and substituted or unsubstituted six-membered heterocycles such as pyrimidine, pyridine and pyridazine; V is chosen from hydrogen, cyano, nitro, -NRxRy, halogen, hydroxyl, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, haloalkyl, haloalkoxy, cycloalkylalkyl, aryl, arylalkyl, biaryl, heteroaryl, heteroarylalkyl, heterocyclic ring and heterocyclylalkyl, -C (O) ORx, -ORx, -C (O) NRxRy -x, Rx-R, -x and SO2NRxRy; or U and V may be joined to form an optionally substituted saturated 3- or 7-membered cyclic ring, which may optionally include one or more heteroatoms chosen from O, S and N; at each occurrence Rx and Ry are independently selected from hydrogen, hydroxyl, halogen, substituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic ring and heterocyclylalkyl; and in each occurrence "m" and "n" are independently selected from 0 to 2, both inclusive. |
| priorityDate | 2009-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 547.