http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2424259-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bb2c65fed767c6cdb08ca3b49dbb9f0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 |
| filingDate | 2007-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b19c40ec481f8bbf507734f463cfdfe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f02db24feb845db042b99b0fa3fb5359 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1def55e52d183726611dce7b81e19125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd9a6d04929edd22cd40f04497915d3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a5e9d21d39b8971801af2482acf93f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1bca9c179fed5737925a89af9ec853d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac26de746207172e43a20545c870e838 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef1793a1c5ce75a0f974d8a8838d7e43 |
| publicationDate | 2013-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2424259-T3 |
| titleOfInvention | Triazoles substituted with polycyclic aryl and polycyclic heteroaryl, useful as inhibitors of Axl |
| abstract | A compound of formula (I): ** Formula ** in which R1, R4 and R5 are independently selected from hydrogen, alkyl, aryl, aralkyl, -C (O) R9 or -C (O) N (R6) R7 One of the R2 and R3 is selected from one of the following and the other is selected from the other two of the following: a) a bicyclic aryl of formula (II) or a bicyclic heteroaryl of formula (II): ** Formula * * where: A is an alkylene chain containing six to ten carbons, an alkenylene chain containing six to ten carbons, or an alkynylene chain containing six to ten carbons, where one or two carbons in the chain of alkylene, alkenylene or alkynylene is optionally replaced by -NR9-,> = N-, -O-, -S (O) p- (where p is 0, 1 or 2) or -P (O) p- (where p is 0, 1 or 2) and wherein each carbon in the alkylene chain, the alkenylene chain or the alkynylene chain is optionally independently substituted with one or two substituents selected from the set consisting of oxo, thioxo, cyano, nitro, halo, haloalkyl, alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl,> = NO-R6, -R10-OR9, R10-O-R11-OR9, -R10-O-R11-O-R11-OR9, -R10-O-R11-CN, -R10-O-R11-C (O) OR9, -R10-O-R11- C (O) N (R6) R7, -R10-O-R11-S (O) pR9 (where p is 0, 1 or 2), -R10-O-R11-N (R6) R7, -R10-O -R11-C (NR12) N (R12) H, -R10-OC (O) -R9, -R10-N (R6) R7, R10-C (O) R9, -R10-C (O) OR9, - R10-C (O) N (R6) R7, -R10-N (R6) C (O) OR9, -R10-N (R6) C (O) R9, -R10-N (R6) S (O) tR9 (where t is 1 or 2), -R10-S (O) tOR9 (where t is 1 or 2), -R10-S (O) pR9 (where p is 0, 1 or 2) and -R10- S (O) tN (R6) R7 (where t is 1 or 2); and B1, B2, B3 and B4 are each independently selected from the set consisting of> = C (R13) - and> = N-, provided that one of the B1, B2, B3 and B4 must be a carbonodirectly bonded with the nitrogen with which its corresponding R2 or R3 is bound; b) a polycyclic heteroaryl containing more than 14 ring atoms, optionally independently substituted with one or more substituents selected from the group consisting of oxo, thioxo, cyano, nitro, halo, haloalkyl, alkyl, optionally substituted cycloalkyl, cycloalkylalkyl optionally substituted, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, -R10-OR9, -R10-O-R11-OR9, -R10-O-R11-O-R11-OR9, -R10-O-R11 -CN, -R10-O-R11-C (O) OR9, -R10-O-R11-C (O) N (R6) R7, -R10-O-R11-S (O) pR9 (where p is 0, 1 or 2), -R10-O-R11-N (R6) R7, -R10-O-R11-C (NR12) N (R12) H, -R10-OC (O) -R9, -R10- N (R6) R7, -R10-C (O) R9, -R10-C (O) OR9, -R10-C (O) N (R6) R7, -R10-N (R6) C (O) OR9, -R10-N (R6) C (O) R9, -R10-N (R6) S (O) tR9 (where t is 1 or 2), -R10-S (O) tOR9 (where t is 1 or 2), -R10-S (O) pR9 (where p is 0, 1 or 2) and -R10-S (O) tN (R6) R7 (where te 1 or 2). |
| priorityDate | 2007-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1053.