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filingDate 2007-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2423454-T3
titleOfInvention Enhanced Cephalosporin Production
abstract A cephalosporin-producing strain of Penicillium that has acquired the ability to produce cephalosporins after being transformed with a gene encoding expandase, and optionally after being further transformed with a gene encoding hydroxylase, a hydroxylase, and an acetyltransferase, or with a hydroxylase and a acetyltransferase and an O-carbamoyl transferase, said Penicillium being capable of producing N-acylated derivatives of 7-ADCA, 7-ADAC, 7-ACA and 7-amino-3-carbamoyl-oxymethyl-3-cephem-4-carboxylic acid, respectively, characterized in that it has been transformed with a heterologous CefT gene that encodes a CefT protein that is a protein involved in the transport of a cephalosporin compound from the interior of the cephalosporin-producing microorganism to the exterior of the cephalosporin-producing microorganism, and with which the relationship of the cephalosporin production capacity of the Penicillium strain transformed with the heterologous CefT gene compared to The ration with the cephalosporin production capacity of the Penicillium strain not transformed with the heterologous CefT gene is at least 1.2.
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