| abstract |
Compound of general formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: A is -Z- (CH2) p- (hetCic2a), -Z- (hetCic5 2b), Z-R10 or Z -R11; Z is O or NH; p is 0, 1 or 2; hetCic2a is a 5- or 6-membered heterocyclic ring, optionally substituted with one or more R9 groups; hetCic2b is a 7 to 12-membered heterobicyclic, bridged or spirocyclic ring system, optionally substituted with one or more R9 groups; R10 is alkyl- (C1-6) substituted with NR'R "; R11 is cycloalkyl- (C5-6) substituted with NR'R"; B is H, CN, ORh, Ar1, hetAr2, C (O) NRiRj, C (O) -hetCic3, C (O) NH (alkyl-C1-6) -hetCic3, C (O) (alkyl-C1-6 ) -hetCic3, SRk, SO2N (C1-6 alkyl) 2, (C1-6 alkyl) NR'R "or alkyl- (C1-3); R1, R2, R3 and R4 are independently H, F, Cl , CN, Me, Et, isopropyl, cyclopropyl, C (O) NR'R ", CH2OH ohetAr3; R1a is H, F, Cl or Me; R5, R6, R7 and R8 are independently H, F, Cl, CN or Me. |