| abstract |
A process comprising the steps of: (α) contacting a solution phase mixture of a radiolabelled product of formula (III) and an excess precursor of formula ++ Formula ** wherein XY is a functional group and R * it is a radioisotope or a radiolabeled portion; with a compound of formula (IV): ** Formula ** in which Z is a eliminating group selected from an isocyanate, isothiocyanate, thiol, hydrazine, hydrazide, aminooxy, 1,3-dipole, aldehyde or ketone; so that the compounds of formulas (IV) and (I) can form a covalent bond with each other; (b) separation of a purified radiolabeled product of formula (III) in the solution phase. |