http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2414679-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed7e4bf98a8d51c2b5f6d46e0c9ee286 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 |
| filingDate | 1998-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4f825c53668a3a015e0f36514feb6b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74055e4c84b425a53f5d966a05880a7d |
| publicationDate | 2013-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2414679-T3 |
| titleOfInvention | Continuous microsphere production method |
| abstract | A continuous method for preparing active agent-containing polymeric microspheres, comprising: a) forming a dispersed phase containing active agent and polymer; b) provide a continuous phase; c) continuously introducing said dispersed phase into a reactor vessel at a dispersed phase feed rate of from 4 ml/minute to 400 ml/minute, and said continuous phase into said reactor vessel at a continuous phase feed rate of 1,000 ml/minute to 20,000 ml/minute, wherein said continuous phase and said dispersed phase are introduced into said reactor vessel at proportions in a ratio of 40:1 to 200:1, the vessel including means for forming an emulsion, and forming a emulsion of the disperse phase in the continuous phase; d) introducing said dispersed phase into said continuous phase in a mixing zone where a shear force or turbulence is caused by a non-static mixer in said reactor vessel, and rotating an impeller of said non-static mixer at a higher mixing intensity than 5,000 revolutions per minute, such that said polymer of the dispersed phase solidifies in said continuous phase in less than 5 seconds after being introduced into said mixing zone, forming a suspension of microspheres; and e) continuously transporting said microsphere suspension from said reactor vessel to a solvent removal vessel to remove solvent from said continuous phase. |
| priorityDate | 1997-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 216.