| abstract |
A compound of formula (I): ** Formula ** in which: R1, R4 and R5 are each independently selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, -C (O) R9 and -C (O) N (R6) R710; R2 and R3 are each, independently, a bicyclic aryl or a bicyclic heteroaryl of formula (II): ** Formula ** in which: A is an alkylene chain containing six to ten carbons, an alkenylene chain which It contains six die carbons, or an alkynylene chain containing six to ten carbons, where one or two carbons of the alkylene, alkenylene or alkynylene chain are optionally replaced by -NR9 -,> = N-, -O-, -S ( O) p- (where p is 0, 1 or 2) or -P (O) p- (where p is 0, 1 or 2) and where each carbon in the alkylene chain, the alkenylene chain or the alkynylene chain is optionally substituted , independently, with one or two substituents selected from the group consisting of oxo, thioxo, cyano, nitro, halo, haloalkyl, alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclyl, - R10-OR9, -R10-O-R1 1-OR925, -R10-O-R11-O-R11-OR9, -R10-O-R11-CN, -R10-O-R11-C (O) OR9, -R10-O-R11-C (O) N (R6) R7, -R10-O-R11-S (O) pR9 (where p is 0, 1 or 2), -R10-O-R11-N (R6) R7, -R10-O-R11-C (NR12) N (R12) H, -R10-OC (O) -R9, -R10-N (R6) R7, -R10-C (O) R9, -R10-C (O) OR9, -R10-C (O) N (R6) R7, -R10-N (R6) C (O) OR14, -R10-N (R6) C (O) R9, -R10-N (R6) S (O) tR9 (wheret is 1 or 2), -R10-S (O) tOR9 (where t is 1 or 2), -R10-S (O) pR9 (where p is 0, 1 or 2) and -R10-S (O) tN ( R6) R7 (where tes 1 or 2); and B1, B2, B3 and B4 are each, independently,> = C (R8) - or> = N-, with the proviso that one of B1, B2, B3 and B4 is a carbon directly attached to the nitrogen at that its corresponding R2 or R3 is attached. |