| abstract |
An oligomer of a length of 7-10 nucleotide bases, comprising a sequence of contiguous nucleotide bases of 7-10 nucleotide bases, in which at least 70% of the nucleotide base units of the oligomer are units of nucleotide bases of acid blocked nucleic (LNA) and in which the oligomer comprises at least one phosphorothioate linkage and in which the oligomer is for use in reducing the effective amount of a target microRNA in a cell or organism. |