| abstract |
An anti-CD40 antibody comprising a light chain variable region and a heavy chain variable region, said heavy chain variable region comprising an amino acid sequence in which: ** Formula ** X1 is I and X2 is V; X1 is L and X2 is I; X1 is V and X2 is V; X1 is L and X2 is L; or X1 is L and X2 is V; and X3 is G, A, V, L, I, P, F, M, W, C, N, Q, S, T, Y, D, E, K, R or H; X4 is G, A, V, L, I, P, F, M, W, C, N, Q, S, T, Y, D, E, K, R or H; and X5 is G, A, V, L, I, P, F, M, W, C, N, Q, S, T, Y, D, E, K, R or H; and said variable domain comprising lightly decays an amino acid sequence. |