http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2404076-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 |
| filingDate | 2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4535a4eae8bb559ed558aea0639c638c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ab77634fa1c5c10678b83b5aa3f78f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de6be8cc84d79459d55ea96bb08b929e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32445f057ce58613f8c8ae27e2642d69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83413618aa6a15ca8b99b862f10a8ecf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d361c8cd448909c6953bdb08cd51e78 |
| publicationDate | 2013-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2404076-T3 |
| titleOfInvention | Quinazoline derivatives as NK3 receptor antagonists |
| abstract | Compound of the general formula I: ** Formula ** in which: R1 is hydroxy or NR'R ", R 'and R' 'are, independently of each other, hydrogen, C1-8-alkyl, cycloalkyl or can form together with the N atom to which a heteroalkyl ring is attached, R2 is hydrogen, C1-8-alkyl, C1-8-alkoxy, halogen, halogen-substituted-C1-8-alkyl, halogen-substituted-C1-8-alkoxy, cyano or S (O) 2-C1-8-alkyl, R3 is C1-8-alkyl, - (CH2) m-aryl, optionally substituted with halogen, or is - (CH2) m-cycloalkyl, R4 and R5 are, independently one on the other, hydrogen or halogen-substituted C1-8-alkyl or are - (CR2) m-aryl or - (CR2) m-heteroaryl, in which the rings can be substituted with one or more substituents, selected from halogen, alkyl- C1-8, C1-8-alkyl substituted with halogen, cyano, hydroxy, NR'R '' or with C1-8-alkoxy substituted with halogen, or are - (CR2) m-cycloalkyl, optionally substituted with hydroxy or with aryl, or are a heteroalkyl ring, or optionally substituted with> = O or with - (CR2) m-aryl, or R4 and R5 are, together with the N atom to which are attached a heterocyclic ring system optionally substituted with C1-8 alkyl, aryl or aryl substituted with halogen, and R can be, independently, hydrogen, C1-8-alkyl or hydroxyl-substituted C1-8-alkyl, n is 1 or 2, m is 0, 1 or 2, or a pharmaceutically active salt, a racemic mixture, an enantiomer, an optical isomer or an auto-formate thereof, in which aryl refers to a cyclic aromatic hydrocarbon radical consisting of one or more fused rings containing 6 to 14 carbon atoms in which at least one ring is of nature Aromatic, heteroaryl refers to a cyclic aromatic hydrocarbon radical consisting of one or more fused rings containing 5 to 14 ring atoms, in which at least one ring is aromatic in nature, and containing at least one heteroatom, selected or from N, O or S; Heteroalkyl ring refers to an alkyl ring of five or six elements, in which one or two carbon atoms are replaced by N, S or O. |
| priorityDate | 2008-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 464.