| abstract |
Cosmetic, non-therapeutic method, for the prevention, deceleration or inversion of dermal aging processes, selected from the set consisting of chronological aging and photoaging, where the composition of the extracellular matrix (ECM) of a mammal is altered by use of one or more protein (s) related to GDF-5 and / or one or more nucleic acid (s) encoding said protein (s), wherein a protein GDF-5 related is any naturally occurring or artificially created protein that comprises a cystine knot domain with an amino acid identity of at least 60% with the 102 aa cystine knot domain of GDF-5 human (amino acids 400-501 of SEQ ID NO: 1). |