| abstract |
A pharmaceutical preparation in the form of a suspension for oral administration of an acid-labile active ingredient in which a plurality of individual units of active ingredient are dispersed in a thickened base composed of one or more pharmaceutical excipients, where the individual units of ingredient active are microspheres and wherein the acid labile active compound is selected from the group consisting of an acid labile proton pump inhibitor, a salt of an acid labile proton pump inhibitor with a base and a hydrate of a salt of an acid labile proton pump inhibitor as a base, and is present in the individual active ingredient units in a matrix composed of a mixture comprising at least one solid paraffin and one or more substances from the group of fatty alcohols, triglycerides and fatty acid esters, and where the thickened base is aqueous sa, and there is present as an excipient at least one thickener selected from the group of substituted celluloses, polyvinylpyrrolidone of the types polyividone, lamellar silicates, alginates, alginic acids and mixtures thereof. |