http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2402664-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2006-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be998a7750e4750f7ee838ac4aa5606e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57c66a111cfc917bf95bde221bdb7796 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f10441d4cb76b10416ed28b727c579a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71d6558dc1835863dfbc6c83ce110667 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7264fe7a95bf96f1be113b6887a6ec3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19734414d5b2ae286bc24060d353bf2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c06c000d609ed49f6a58a6bffcc66faf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f51cfb21347a733ce6f97d8cd39d2327 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8090390dd26cc3351561be912cc4d41b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e6da9eb4d0f99f1ffcf4a12012e9edf |
| publicationDate | 2013-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2402664-T3 |
| titleOfInvention | Condensed heterocyclic compounds useful as kinase modulators |
| abstract | A compound according to formula (I), or an eUn compound according to formula (I), or an eUn compound according to formula (I), or an enantiomer, diastereomer, or a pharmaceutically, salt, diastereomer, or a pharmaceutical salt, diastereomer, or a pharmaceutically acceptable salt thereof, in which: E is C; F is an acceptable entity thereof, in which: E is C; F is an acceptable entity thereof, in which: E is C; F is N; X is NR4R5; Z is CR3; And it is selected from N; X is NR4R5; Z is CR3; And it is selected from N; X is NR4R5; Z is CR3; Y is selected from hydrogen, halogen, nitro, cyano, SR8, S (O) pR8, hydrogen, halogen, nitro, cyano, SR8, S (O) pR8, hydrogen, halogen, nitro, cyano, SR8, S (O) pR8, OR8, NR6R7, CO2R8, C (> = O) R8, OC (> = O) R8, C (> = O) NR8ROR8, NR6R7, CO2R8, C (> = O) R8, OC (> = O) R8, C (> = O) NR8ROR8, NR6R7, CO2R8, C (> = O) R8, OC (> = O) R8, C (> = O) NR8R9, cycloalkyl, cycloalkenyl, cycloalkynyl, h9, cycloalkyl, cycloalkenyl, cycloalkynyl, h9, cycloalkyl, cycloalkenyl, cycloalkynyl, heterocycle, aryl, and heteroaryl, with the condition ether, aryl, and heteroaryl, with the condition ether, aryl, and heteroaryl, with the condition that if Y is hydrogen, then R4 is phenyl if Y is hydrogen, then R4 is phenyl sude if Y is hydrogen, then R4 is phenyl substituted with a carboxamido group; R1 and R2 are constituted with a carboxamido group; R1 and R2 are constituted with a carboxamido group; R1 and R2 are independently selected from (i) hydrogen selects two independently from (i) hydrogen independently selected from (i) hydrogen, alkyl, halogen, nitro, cyano, SR10, OR10, NR10, alkyl, halogen, nitro, cyano, SR10, OR10, NR10, alkyl, halogen, nitro, cyano, SR10, OR10, NR10R11, NR10C (> = O) R11, CO2R10, C (> = O) R10, -OC (> = O) R1R11, NR10C (> = O) R11, CO2R10, C (> = O) R10 , -OC (> = O) R1R11, NR10C (> = O) R11, CO2R10, C (> = O) R10, -OC (> = O) R10, C (> = O) NR10R11; R3 is selected from hydro0, C (> = O) NR10R11; R3 is selected from hydro0, C (> = O) NR10R11; R3 is selected from hydrogen, halogen, alkyl, substituted alkyl, alkenogen, halogen, alkyl, substituted alkyl, alkenogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, alkynyl sunyl, substituted alkenyl, alkynyl, alkynyl sunyl, alkenyl substituted, alkynyl, substituted alkynyl, nitro, cyano, SR13, OR13, NR13R14, NR13Constructed, nitro, cyano, SR13, OR13, NR13R14, NR13Constructed, nitro, cyano, SR13, OR13, NR13R14, NR13C (> = O) R14, CO2R13 , C (> = O) R13, -O15C (> = O) R13, -C (> = O (> = O) R14, CO2R13, C (> = O) R13, -O15C (> = O) R13, -C (> = O (> = O) R14, CO2R13, C (> = O) R13, -O15C (> = O) R13, -C (> = O) NR13R14, cycloalkyl, heterocycle, aryl, and hete) NR13R14, cycloalkyl, heterocycle, aryl, and hete) NR13R14, cycloalkyl, heterocycle, aryl, and heteroaryl; R4, R5, R6, and R7 are selected inderoaryl; R4, R5, R6, and R7 are selected inderoaryl; R4, R5, R6, and R7 are independently selected from hydrogen, alkyl, alkyl spendiently from hydrogen, alkyl, alkyl spendiently from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkyl substituted, alkenyl, substituted alkenyl, alkyl substituted, alkenyl, alkenyl substituted, alkynyl, substituted alkynyl, OR15, SR15, C (> = O) R15, Clo, substituted alkynyl, OR15, SR15, C (> = O) R15, Clo, substituted alkynyl, OR15, SR15, C (> = O ) R15, CO2R15, C (> = O) NR15R16, C (W) OR16, S (O) pR17, SO2NR15R1O2R15, C (> = O) NR15R16, C (W) OR16, S (O) pR17, SO2NR15R1O2R15, C (> = O) NR15R16, C (W) OR16, S (O) p17, SO2NR15R16, cycloalkyl, heterocycle, aryl, and heteroaryl6, cycloalkyl, heterocycle, aryl, and heteroaryl6, cycloalkyl, heterocycle, aryl, and heteroaryl; or (ii) R4 is taken together with R5 and the nitr atom; or (ii) R4 is taken together with R5 and the nitr atom; or (ii) R4 is taken together with R5 and the nitrogen atom to which both are attached and / or R6 is taken junogen to which both are attached and / or R6 is taken junogen to which both are attached and / or R6 is taken together with R7 and the nitrogen atom that both are static with R7 and the nitrogen atom that both are static with R7 and the nitrogen atom that both are linked to form a heteroaryl or heterocyclic attached to form a heteroaryl or heterocyclic attached to form a heteroaryl or a heterocycle; R8, R9, R10, R11, R13, R14, R15, and R16 in each; R8, R9, R10, R11, R13, R14, R15, and R16 in each; R8, R9, R10, R11, R13, R14, R15, and R16 in each occurrence are independently selected occurrence are independently selected occurrence are independently selected from (i) hydrogen, alkyl, substituted alkyl, among (i) hydrogen, alkyl, alkyl substituted, aentre (i) hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, alkynylkenyl, substituted alkenyl, alkynyl, alkynylkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, aryl, heteroaryl, and substituted, cycloalkyl , heteroaryl, and the substituted, cycloalkyl, aryl, heteroaryl, and heterocycle; or (ii) together with the nitrogenoheterocycle atom; or (ii) together with the nitrogenoheterocycle atom; or (ii) together with the nitrogen atom to which they are attached, R8 setoma together with R9, and / or or to which they are attached, R8 setoma together with R9, and / or or to which they are attached, R8 setoma together with R9, and / or R10 is taken together with R11, and / or R13 is taken together R10 is taken together with R11, and / or R13 is taken together R10 is taken together with R11, and / or R13 is taken together with R14, and / or R15 is taken together with R16 to form with R14, and / or R15 is taken together with R16 to form with R14, and / or R15 is taken together with R16 to form a heteroaryl or a heterocycle; R17 is selected from a heteroaryl or a heterocycle; R17 is selected from a heteroaryl or a heterocycle; R17 is selected from alkyl, substituted alkyl, alkenyl, swim between alkyl, substituted alkyl, alkenyl, swim between alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, alkylsubstituted alkenyl substituted, alkynyl, alkylsubstituted substituted alkenyl, alkynyl, alkylsubstituted, cycloalkyl aryl, heteroaryl, and heterocyclic, cycloalkyl, aryl, heteroaryl, and heterocyclic, cycloalkyl, aryl, heteroaryl, and heterocycle; W at each occurrence is O, S, N, CN, or NH; and p lo; W at each occurrence is O, S, N, CN, or NH; and p lo; W at each occurrence is O, S, N, CN, or NH; and p is 1 or 2, with the following conditions: (1) if X is 1 or 2, with the following conditions: (1) if X is 1 or 2, with the following conditions: (1) if X is NH (Me), N (Me) 2, NH (unsubstituted phenyl), or NH is NH (Me), N (Me) 2, NH (unsubstituted phenyl), or NH is NH (Me), N (Me) 2, NH ( unsubstituted phenyl), or NHNH2, then Y is different from hydrogen or dehalogoNH2, then Y is different from hydrogen or dehalogoNH2, then Y is different from hydrogen or dehalogen; and (2) the following compounds are excluded; and (2) the following compounds are excluded; and (2) the following compounds are excluded: os: os: |
| priorityDate | 2005-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1073.