http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2401482-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a73cee5001ad08339ae751c10d9abf71 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4245 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-08 |
| filingDate | 2006-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93f836b99512f2719ae3e9542c22df85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a76e8bc72a90ebbf0e7e005360bcbfe |
| publicationDate | 2013-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2401482-T3 |
| titleOfInvention | Indolamine 2,3-dioxygenase modulators and methods of use thereof |
| abstract | A compound of Formula: ** Formula ** or pharmaceutically acceptable salt thereof wherein: W, X1 and X2 are independently selected from (CRaRb) t, (CRaRb) or O (CRaRb) v, (CRaRb) uC (O) ( CRaRb) v, (CRaRb) uC (O) NRc (CRaRb) v, (CRaRb) uC (O) O (CRaRb) v, (CRaRb) uC (S) (CRaRb) u, (CRaRb) uC (S) NRc (CRaRb) v, (CRaRb) uS (O) (CRaRb) v, (CRaRb) uS (O) NRc (CRaRb) v, (CRaRb) uS (O) 2 (CRaRb) v, (CRaRb) uS (O) 2NRc (CRaRb) v, (CRaRb) uNRc (CRaRb) v, and (CRaRb) uC (> = NRd) NRc (CRaRb) v; R2 is H, C1-6 alkyl, or C3-7 cycloalkyl; R3a and R5a are independently selected from C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, heteroarylocycloalkyl, and heterocycloalkyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halo, C1 alkyl -6, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, Cy1, CN, NO2, ORe1, SRe1, C (O) Rf1, C (O) NR91Rh1, C (O) ORe1, OC (O) Rf1, OC (O) NR91Rh1, NR91C (O) NR91Rh1, NR91Rh1, NR91C (O) Rf1, NR91C (O) ORe1, C (> = NRi) NR91Rb1, NR91C (> = NR ') NR91Rb1, P (Rfl) 2 , p (ORe1) 2, P (O) Re1Rf1, P (O) ORe1ORf1, S (O) Rf1, S (O) NR91Rb1, S (O) 2Rf1, and S (O) 2NR91Rh1; R3b is aryl or heteroaryl each optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halo, C1-8 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1- hydroxy alkyl, Cy2, CN, NO2, ORe1, SRe1, C (O) Rf1, C (O) NR91Rh1, C (O) ORe1, OC (O) Rf1, OC (O) NR91Rh1, NR91C (O) NR91Rh1, NR91Rh1, NR91C (O) Rf1, NR91C (O) ORe1, C (> = NRi) NR91Rh1, NR91C (> = NRi) NR91Rh1, P (Rf1) 2, P (ORe1) 2, P (O) Re1Rf1, P (O) ORe1ORf1, S ( O) Rf1, S (O) NR91Rh1, S (O) 2Rf1, and S (O) 2NR91Rh1; R5b is H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl wherein said C1-8 C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl is each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-4 Cy2 hydroxyalkyl, CN, NO2, ORe1, SRe1, C (O) Rf1, C (O) NR91Rh1, C (O) ORe1, OC (O) Rf1, OC (O) NR91Rh1, NR91C (O) NR91Rh1, NR91Rh1, NR91C (O) Rf1, NR91C (O) ORe1, C (> = NRi) NR91Rh1, NR91C (> = NRi) NR91Rh1, P (Rf1) 2, P (ORe1) 2, P (O) Re1Rf1, P (O) ORe1ORf1, S ( O) Rf1, S (O) NR91Rh1, S (O) 2Rf1, and S (O) 2NR91Rh1; Cy1 and Cy2 are independently selected from aryl, cycloalkyl, heteroaryl and heterocycloalkyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, haloalkyl C1-4, CN, NO2, ORe3, SRe3, C (O) Rf3, C (O) NR93Rh3, C (O) ORe3, OC (O) Rf3, OC (O) NR93Rb3, NR93Rh3, NR93C (O) Rh3, NR93C (O) ORe3, C (> = NRi) NR91Rh1, NR91C (> = NRi) NR91Rh1, P (Rf3) 2, P (ORe3) 2, P (O) Re3Rf3, P (O) ORe3ORf3, S (O) Rf3, S (O) NR9Rh3, S (O) 2Rf3, and S (O) 2NR93Rh3; Ra and Rb are independently selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, heterocycloalkylalkyl, CN, NO2 , ORe4, SRe4, C (O) Rf4, C (O) NR94Rh4, C (O) ORe4, OC (O) Rf4, OC (O) NR94Rh4, NR94Rh4, NR94C (O) Rh4, NR94C (O) ORe4, C (> = NRi) NR91Rh1, NR91C (> = NRi) NR91Rh1, P (Rf4) 2, P (ORe4) 2, P (O) Re4Rf4, P (O) ORe4ORf4, S (O) Rf4, S (O) NR94Rh4 , S (O) 2Rf4, and S (O) 2NR94Rh4; Rc is H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, arylalkyl, or cycloalkylalkyl; Rd is H, ORd1, CN or NO2. |
| priorityDate | 2005-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1002.