abstract |
A compound of formula 2 in which: ** Formula ** R1 is selected from C6-12 aryl, 5-12 membered heteroaryl, C3-12 cycloalkyl or 3-12 membered heteroalicyclic; and each hydrogen in R1 is optionally substituted with one or more R3 groups; R2 is hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl or C6-12 aryl; R3 is halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl, C6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, S (O) mR4, SO2NR4R5 , S (O) 2OR4, NO2, NR4R5, (CR6R7) nOR4, CN, C (O) R4, OC (O) R4, O (CR6R7) nR4, NR4C (O) R5, (CR6R7) nC (O) OR4 , C (> = NR6) NR4R5, NR4C (O) NR5R6, NR4S (O) pR5 or C (O) NR4R5, each hydrogen in R3 is optionally substituted with one or more R8 groups, and R3 groups in adjacent atoms can be combined to form a C6-12 aryl group, 5-12 membered heteroaryl, C3-12 cycloalkyl or 3-12 membered heteroalicyclic; each R4, R5, R6 and R7 is independently hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2 12 alkynyl, C3-12 cycloalkyl, C6-12 aryl, 3-12 membered heteroalicyclic, 5-12 heteroaryl members; or any two of R4, R5, R6 and R7 attached to the same nitrogen atom can, together with the nitrogen to which they are attached, combine to form a 3-12 membered heteroalicyclic or 5-12 membered heteroaryl optionally containing 1 to 3 additional heteroatoms selected from N, O and S; or any two of R4, R5, R6 and R7 attached to the same carbon atom can be combined to form a C3-12 cycloalkyl, C6-12 aryl, 3-12 membered heteroalicyclic or 5-12 membered heteroaryl group; and each hydrogen in R4, R5, R6 and R7 is optionally substituted with one or more R8 groups; each R8 is independently halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl, C6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, CN, O- alkyl C1-12, O- (CH2) nC3-12 cycloalkyl, aryl O- (CH2) nC6-12, O- (CH2) n (3-12 membered heteroalicyclic) or O- (CH2) n (5- heteroaryl 12 members); and each hydrogen in R8 is optionally substituted with one or more R11 groups; A1 is (CR9R10) n-A2; each R9 and R10 is independently hydrogen, halogen, C1-12 alkyl, C3-12 cycloalkyl, C6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, S (O) mR4, SO2NR4R5, S (O ) 2OR4, NO2, NR4R5, (CR6R7) nOR4, CN, C (O) R4, OC (O) R4, NR4C (O) R5, (CR6R7) nC (O) OR4, 30 NR4C (O) NR5R6, NR4S ( O) pR5 or C (O) NR4R5; R9 and R10 can be combined to form a C3-12 cycloalkyl, 3-12 membered heteroalicyclic, C6-12 aryl or 5-12 membered heteroaryl ring; and each hydrogen in R9 and R10 is optionally substituted with one or more R3 groups; A2 is C6-12 aryl, 5-12 membered heteroaryl, C3-12 cycloalkyl or 3-12 membered heteroalicyclic and A2 is optionally substituted with one or more R3 groups; each R11 is independently halogen, C1-12 alkyl, C1-12 alkoxy, C3-12 cycloalkyl, C6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, O-C1-12 alkyl, O- cycloalkyl (CH2) nC3-12, aryl O- (CH2) nC6-12, O- (CH2) n (3-12 member heteroalicyclic), O- (CH2) n (5-12 member heteroaryl) or CN, and each hydrogen in R11 is optionally substituted with one or more groups selected from halogen, OH, CN, C1-12 alkyl which may be partially or completely halogenated, O-C1-12 alkyl which may be partially or completely halogenated, CO, SO and SO2; R12 is hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl or C8-12 aryl; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4; and 45 p is 1 or 2; or a pharmaceutically acceptable salt, solvate or hydrate thereof. |