http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2400622-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c851e729089df9a427027272fa290 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-28 |
| filingDate | 2008-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4bce35ea997f32000689bbe76020f68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c119f394298ae9b4bac559880181bbaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22f121137cf733f7bff384e5c0718566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b88bb80a79bd194b85ddc5fd8b8f772 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_474821c27cb94bce81649e75d7361cf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24ccc95c0323d4d4f154269922ce973c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b59749539491713014ad56cc8a9de7c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4f563ed693e010f6529662b76cb13b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4524cd001ec2456c49afa720c26996c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d4e7ce51eb4920a5a6d7357c966bc76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bca6d493d6867f43833b91cdf55aac4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce7fe7261a74998f50bde8516318658e |
| publicationDate | 2013-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2400622-T3 |
| titleOfInvention | Hydrazide pyrimidine compounds as PGDS inhibitors |
| abstract | A compound of formula (I): where: R1 is phenyl, pyridyl, pyrimidinyl, thiazolyl, or oxadiazolyl, each of which is optionally substituted one or more times independently with halo, (C1-C6) alkyl, hydroxy or (C1 -C6); R2 is hydrogen, methyl or trifluoromethyl; L1 is a link; R3 and R4 together with the nitrogen atom to which they are attached form [1,2,4] triazolyl, pyrrolyl, indolyl, pyrrolo [2,3-b] pyridyl, pyrrolo [3,2-b] pyridyl or pyrrolo [2 , 3-c] pyridyl, each optionally substituted one or more times independently with R6; and R6 is alkoxy, carboxy, cycloalkyl, halo, cyano, alkylsulfonyl, Y1Y2N-SO2-, alkyl optionally substituted one or more times independently with acyloxy, hydroxy, alkoxycarbonyl, alkoxy, carboxy, aryl, halo, heterocyclyl, alkylsulfonyl, cyano, heterocyclylcarbonyl , acyl or aryl, each optionally substituted one or more times independently with halo, alkoxycarbonyl optionally substituted one or more times independently with aryl, heteroaryl optionally substituted one or more times independently with alkyl, heterocyclyl optionally substituted one or more times with oxo, or aryloxy optionally substituted one or more times independently with haloalkyl, or R3 and R4 together with the nitrogen atom to which they are attached form imidazolidinyl, [1,2,4] triazinanyl, piperazinyl, morpholinyl, pyrrolidinyl, 1,2,3,4 -tetrahydropyrimidinyl, piperidinyl, oxazolidinyl, 2,3-dihydroindolyl, octahydro-cyclopenta [c] pyrrolyl or 3,4-dihydro-benzo [1,4] oxaz ina, each of them optionally substituted one or more times independently with R6; and R6 is oxo, alkoxy, carboxy, cycloalkyl, halo, cyano, alkylsulfonyl, Y1Y2N-SO2-, alkyl optionally substituted one or more times independently with hydroxy, alkoxycarbonyl, alkoxy, carboxy, aryl, halo, heterocyclyl, alkylsulfonyl, cyano, heterocyclylcarbonyl , acyl or aryl, each optionally substituted one or more times independently with halo, alkoxycarbonyl optionally substituted one or more times independently with aryl, heteroaryl optionally substituted one or more times independently with alkyl, heterocyclyl optionally substituted one or more times with oxo, or aryloxy optionally substituted one or more times independently with haloalkyl, each of Y1 and Y2 is independently hydrogen or alkyl optionally substituted with morpholinyl or Y1 and Y2 together with the nitrogen atom to which they are attached form morpholinyl; or a hydrate, solvate or N-oxide thereof, or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2007-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1376.