| abstract |
A compound having the general formula (I) in which A is O or NH; X is-CR5R6 in which R5 and R6 are independently selected from the group consisting of H, CH3, C2H5, i-C3H7, n-C3H7, i-C4H9, n-C4H9, sec-C4H9, and tert-C4H9; wherein in any of the alkyl groups one or more H atoms may be optionally substituted with one or more substituents independently selected from the group consisting of OH, F, Cl, Br and I; or R5, R6 together with the carbon atom to which they are attached form a cyclopropyl ring; R1, R2, R3 and R4 are independently selected from the group consisting of H, OH, C (1-4) alkyl, C (1-4) alkoxy, - N (CH3) 2, -SO2CH3, CN, OCF3, - C (O) CH3, OCH3, CF3, F and Cl; wherein said C (1-4) alkyl and C (1-4) alkoxy are optionally substituted independently with one, two or three substituents selected from the group consisting of I, Br, F and Cl; Y is CO2H; R9 and R10 are independently H, F or CF3; and its solvates, hydrates, esters and pharmaceutically acceptable salts. |