| abstract |
An isolated and purified DNA sequence that has an activity that increases protein production, characterized in that said DNA sequence comprises a) at least one curved DNA element, where the curved DNA element contains at least 33% of TA dinucleotide and / or at least 33% of the AT dinucleotide in a contiguous 100 base pair span, b) at least one binding site for a DNA binding protein, and because it is a MAR nucleotide sequence having the sequence SEQ ID No 27, or one of its complementary sequences, or a sequence that has an identity of at least 90% with said sequence SEQ ID No 27. |