| abstract |
A compound represented by formula (I) where R1 represents (1) a hydrogen atom, (2) C1-4alkyl, (3) C2-4alkenyl or (4) benzyl; E represents -CO-, -SO2- or -CH2-; R2 represents (1) a halogen atom, (2) C1-6 alkyl, (3) C1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl , (9) nitro, (10) -NR6R7 or (11) C1-4 alkyl substituted with -OR8, (12) oxidized C1-6 alkyl, (13) -SO2R11, (14) -SOR11 or (15) -SR11 , or two R2substituting the adjacent carbon atom are taken together to represent (1) C2-5 alkylene, which may be substituted by a substituent, where a carbon atom thereof may be replaced by an oxygen atom, a nitrogen atom or a sulfur atom, which may be oxidized, or (2) C2-5 alkenylene, which may be substituted with a substituent, where a carbon atom thereof may be replaced with an oxygen atom, a nitrogen atom, or a sulfur atom ; R3 represents (1) a halogen atom, (2) C1-6 alkyl, (3) C1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl , (9) nitro, (10) -NR6R7 or (11) C1-4 alkyl substituted with -OR8, (12) oxidized C1-6 alkyl, (13) -SO2R11, (14) -SOR11 or (15) -SR11 ; R6 and R7 each independently represent a hydrogen or C1-4alkyl atom; R8 represents C1-4 alkyl, phenyl or pyridyl; R4 represents (1) a hydrogen atom, (2) C1-6 alkyl, (3) benzyl or (4) oxidized C1-6 alkyl; R5 represents (1) C1-6 alkyl, (2) C1-10 alkoxy, (3) C1-6 alkyl substituted with C1-6 alkoxy, (4) a halogen atom, (5) hydroxyl, (6) trihalomethyl, (7) nitro, (8) -NR9R10, (9) phenyl, (10) phenoxy, (11) oxo, (12) C2-6 acyl, (13) cyano or (14) -SO2R11, (15) -SOR11 , (16) -SR11 or (12) oxidized C 1-6 alkyl; R9 and R10 each independently represent a hydrogen atom or C1-4alkyl, and R11 represents C1-6alkyl or phenyl, which may be substituted; where R6 to R11 in R2 to R5 may be the same or each independently different. |