http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2398618-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81ad53b64eb74859acdc01278829b080 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-60 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2009-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f577167ad427d3f25efc4be67a815628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64ede06129ca9bdb3658397df2cb225e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78eec8aedb2d2d62f95bd9cb63f0b4f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8a45b33b2bff10bb2f6cf6eb778fe78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66cc87061487cab00ae1de196919a322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99288171296aef0574f4d354b224a373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a44551494f0ba35456c2423f95d495e |
| publicationDate | 2013-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2398618-T3 |
| titleOfInvention | Drug selection for breast cancer therapy using antibody matrices |
| abstract | Method comprising: (a) lysing cells of an isolated breast tumor after administration of an anticancer drug, or prior to incubation with an anticancer drug, to produce a cell extract, (b) detecting an activation state of one or more analytes in the cell extract using an assay that comprises a plurality of dilution series of specific capture antibodies of one or more analytes, in which the capture antibodies are immobilized on a solid support, and in which the assay comprises: (i) incubating the cell extract with a plurality of dilution series of capture antibodies to form a plurality of captured analytes, (ii) incubating the plurality of analytes captured with detection antibodies comprising a plurality of antibodies independent of the activation state and a plurality of dependent antibodies specific activation status for the corresponding analytes in order to form or a plurality of detectable captured analytes, in which the independent activation state antibodies are labeled with glucosidase oxidase, in which the glucose oxidase and the independent deactivation state antibodies are conjugated with a sulfhydryl activated dextran molecule, in which the dependent antibodies of the activation state are marked with a first member of a signal amplification pair and in which glucose oxidase generates an oxidizing agent that is channeled and reacts with the first member of the signal amplification pair, (iii) incubating the plurality of captured analytes detectable with a second member of the signal amplification partner to generate an amplified signal, and (iv) detect the amplified signal generated from the first and second members of the signal amplification partner, and (c) determine whether the drug Anticancer is appropriate or inappropriate for the treatment of breast tumor before comparing the activation status detected for one or more analytes with a reference activation profile generated in the absence of the anti-cancer drug, in which the method is intended for the selection of an anti-cancer drug suitable for the treatment of a breast tumor. |
| priorityDate | 2008-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1791.