| abstract |
Transdermal therapeutic system comprising a backing layer, a protective layer and at least one polymer matrix with active substance content, the active ingredient being a steroid hormone or a combination of steroid hormones, and the polymer matrix base polymer consisting of a polyacrylate adhesive adhesive. contact which is a homopolymer, copolymer or block copolymer, which can be prepared by polymerization of a mixture of monomers consisting of: a) a monomer or a mixture of monomers of the group of esters of acrylic acid or methacrylic acid bearing C1- substituents C12 linear, branched and / or cyclic aliphatic, without other functional groups, b) optionally acrylic acid, methacrylic acid, 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, 3-hydroxypropyl acrylate and / or 3-hydroxypropyl methacrylate, finding the sum of the proportion of these monomers below 2% by weight, c) eventually vinyl acetate in a proportion below 20% by weight, d) eventually crosslinking agents in a proportion below 0.5% by weight, e) possibly adjuvants of the group of antioxidants, stabilizers and / or alkyl mercaptans in a proportion below 0.1% by weight. |