abstract |
A compound of Formula I: in which: R1 is hydrogen; each of R2, R3 and R4 is hydrogen; R5 is hydrogen; R6 is -NR10R11; R7 is halo; R8 is hydrogen; R9 is hydrogen; R10 is Ph2-methyl or Ar1-methyl; R11 is hydrogen; Ph1 is phenyl optionally substituted with 1 to 5 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, -SCF3, (C1-C6) alkyl optionally further substituted with 1 to 6 fluorine substituents , and (C1-C6) alkoxy optionally further substituted with 1 to 6 fluorine substituents; Ph2 is phenyl substituted with R12 and optionally further substituted with 1 or 2 substituents independently selected from the group consisting of halo, cyano, -SCF3, methyl, -CF3, hydroxy and methoxy. |