| abstract |
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: Y is a covalent bond, phenylene group or substituted or unsubstituted straight chain hydrocarbyl group, or, Y together with both groups> C> = To which it is attached, it is a substituted or unsubstituted aromatic group; R1 is an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; R2-R4 are independently -H, an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, a substituted non-aromatic heterocyclic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon atoms and nitrogen to which they are attached, and / or R2 and R4 taken together with the carbon and nitrogen atoms to which they are attached, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring; R5-R6 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group; and Z is> = O or> = S; for use in the treatment of melanoma or kidney cancer by administration of said compound, in the same or separate pharmaceutical composition, with paclitaxel or a paclitaxel analog. |