http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2392996-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-02 |
| filingDate | 2007-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4403fb27c2b942ef0f47edb00a32bae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b22ff1d51c21c66f84c512cae80cbeae |
| publicationDate | 2012-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2392996-T3 |
| titleOfInvention | Process for the preparation of pyrazolilaminoquinazoline derivatives containing a phosphate group |
| abstract | A process for preparing an intermediate compound of formula (II) formula (II) in which A is a member heteroaryl containing a nitrogen atom and optionally containing 1, 2 or 3 additional nitrogen atoms; X is -NH- or -N (C1-4 alkyl) -; m is 0, 1, 2 or 3; R1 is C1-6 alkyl substituted with -OP (O) (OH) (OR) and optionally further substituted with 1 or 2 C1 groups- 4 alkoxy; R2 is hydrogen or C1-6 alkyl optionally substituted with 1, 2 or 3 C1-4 alkoxy groups or -S (O) pR8 (where p is 0, 1 or 2), or R2 is a group selected from C2- 6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl and C3-6 cycloalkylC1-4 alkyl; or R1 and R2, together with the nitrogen to which they are attached, form a 5- to 7-membered ring, which ring can be unsaturated, unsaturated or partially saturated, wherein the ring is substituted with a group selected from -OP (O) (OH) (OR) and C1-4 alkyl, said C1-4 alkyl being substituted with -OP (O) (OH) (OR ), and where the ring is optionally replaced as well s with 1, 2 or 3 C1-4 alkyl groups; R3 is a group selected from hydrogen, halo, cyano, nitro, C1-6 alkoxy, C1-6 alkyl; R4 is hydrogen or a group selected from C1-4 alkyl, heteroaryl, heteroarylC1-4 alkyl, aryl and arylC1-4 alkyl, group that is optionally substituted with 1, 2 or 3 substituents selected from methyl, ethyl, cyclopropyl yetinyl; R5 is selected from hydrogen, C1-4 alkyl, C2-4 alkenyl , C2-4 alkynyl, C3-6 cycloalkyl and C3-6 cycloalkylC1-4 alkyl; R6 and R7 are independently selected from hydrogen, C1-4 alkyl, C3-6 cycloalkyl, and C1-4 alkoxy; R8 is hydrogen or C1- 4 alkyl, wherein R is a labile protecting group in acidic medium selected from tert-butyl, trityl, p-methoxyphenyl, benzyl ofenyl. |
| priorityDate | 2006-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 177.