| abstract |
A compound selected from the formula I: and stereoisomers and pharmaceutically acceptable salts thereof, wherein: R1 and R2 are independently selected from hydrogen, halogen, CN, C1-C3 alkyl and C1-C3 alkoxy; R3 is hydrogen, halogen or C1-C3 alkyl; R4 is C3-C5 cycloalkyl, C1-C6 alkyl, C1-C6 alkenyl or C1-C6 alkynyl, wherein the cycloalkyl, alkyl, alkenyl and alkynyl are optionally substituted with ORc, halogen or C3-C4 cycloalkyl; R5 is hydrogen, phenyl optionally substituted with 1 to 3 Ra groups, -N (Rc) -phenyl optionally substituted with Ra.CH2-phenyl optionally substituted with 1 to 3 Rb groups, a 5-6 membered heteroaryl optionally substituted with 1 to 3 groups Re, C3-C6 saturated or partially unsaturated cycloalkyl optionally substituted with halogen or C1-C4 alkyl, a 5-6 membered heterocyclyl or C1-C6 alkyl optionally substituted with one or more Rg groups; each Ra is independently selected from halogen, CN, a 5-6 membered heterocyclyl, NRcRd, -S (O) 2Rf, O (C1-C4 alkyl) and C1-C4 alkyl, in which the alkyl or alkoxy are optionally substituted with halogen; each Rb is independently selected from halogen, OH or OCH3; each Rc and Rd is independently selected from hydrogen or C1-C4 alkyl; Re is selected from a 5-6 membered heterocyclyl or NRcRd; Rf is selected from C1-C4 alkyl or NRcRd; and each Rg is independently selected from halogen, CN, ORc, C3-C6 cycloalkyl or NRcRd. |