| abstract |
A compound having the general formula (I) in which X is a bond or a group -CR5R6, in which R5 and R6 are independently selected from each other in the group consisting of H; alkyl selected from the group CH3, C2H5, i-C3H7, n-C3H7, i-C4H9, n-C4H9, sec-C4H9 and ether-C4H9; alkenyl selected from C2H3, i-C3H5, n-C3H5, n-C4H7, i-C4H7 and sec-C4H7; wherein in any of the alkyl and alkenyl groups one or more H atoms may optionally be substituted with one or more substituents independently selected from the group consisting of OH, F, Cl, Br, I and CF3; or R5 and R6 are part of a ring, saturated or unsaturated, substituted or unsubstituted, of 3 to 6 C atoms, and which may contain the ring one or more heteroatoms of the group N, S or O, and whose heteroatoms may be identical or different if more than one heteroatom is present: R1, R2, R3 and R4 are independently selected from the group consisting of H; F; Cl; Br; I; CN; OH; C (O) N (R7R8); S (O) 2R7; SO2N (R7R8); S (O) N (R7R8); N (R7) S (O) 2R8; N (R8) S (O) R8; S (O) 2R7; N (R7) S (O) 2N (R8R8a); SR7; N (R7R8); N (R7) C (O) R8; N (R7) C (O) N (R8R8a); N (R7) C (O) OR8; OC (O) N (R7R8); C (O) R7; C1-C4 alkyl substituted and unsubstituted and C1-C4 alkoxy substituted and unsubstituted, and where the substituents of both C1-C4 alkyl and C1-C4 alkoxy groups are selected from OH, F, Cl, Br, I, CF3; R7, R8 , R8a are independently selected from the group consisting of H; C1-C4 alkyl; heterocyclyl; and C3-7cycloalkyl, wherein C1-C4 alkyl; heterocyclyl; and the C3-7 cycloalkyl may optionally be substituted with one or more substituents independently selected from the group consisting of OH, F, Cl, Br, I and CF3; R9 and R10 are independently H, F or CF3; Y is a carboxy group C (O) OH or a substituted or unsubstituted tetrazole group and its pharmaceutically acceptable solvates, hydrates, esters and salts. |