| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87a863132c68cf0f62015bbd5d05ab38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0eb3c391d7e38c89f330236184317fc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-244
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
2005-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44289bd435ca1916f418ecc94250cff5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_562f247969efcb1e00d04392d04272e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c197475da6e1f8ccdb6c02dcdb5fbde2 |
| publicationDate |
2012-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2391097-T3 |
| titleOfInvention |
Panning procedure in solution using genetically modified decoy proteins |
| abstract |
A method for identifying an antibody that binds to a preselected epitope of a target protein comprises: a) providing a phage particle library that expresses antibodies on the surface of the phage particles; b) preparing a decoy protein that has changes in the corresponding amino acid sequences preselected alepitope of the target protein, and differing the decoy protein from the target protein only in preselected elepitope; c) incubating the phage particle library with the target protein to select phage particles with protein binding antibodies target; d) add the decoy protein as a competitor at a molar excess concentration to negatively select the phage particles specific for the preselected epitope; e) separate the phage particles that bind to the target protein from those that bind to the decoy protein and f) recover phage particles bound to the target protein |
| priorityDate |
2004-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |