http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2390968-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate | 2005-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b89eba22dfd25a1e34d474d2479cf6ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ddb44ba514100de7c721be69bb47dc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2595b87adf306ae619e0d05e41c47666 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3686dcb070c70ffdaafb6d67d7c36d27 |
| publicationDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2390968-T3 |
| titleOfInvention | Modulators of glucocorticoid receptor activity, AP-1, and / or NF-kB and its use |
| abstract | A compound having the structure of formula (I): stereoisomers thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, aryl, arylalkyl, aryloxy, heteroaryl, cycloheteroalkyl, heteroarylalkyl, cycloheteroalkylalkyl, cycloalkyl, cycloalkylalkyl, cyanoalkyl, aminoalkyl, hydroxyalkyl, aryloxyalkyl, or hydroxyaryl; Ra and Rb are independently selected from hydrogen, halogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, aryl, aryloxy, heteroaryl , cycloheteroalkyl, heteroarylalkyl, cycloheteroalkylalkyl, cyano, heteroarilaminocarboilo, cycloheteroalkylcarbonyl, cyanoalkyl, alkylaminoalkyl, hydroxyalkyl, hydroxyaryl, aryloxyalkyl, alkyloxyalkyl, nitro, NR e R f, CHO, CO2alkyl, CONReRf, CH2NReRf, CO2H, CH2OH, CH2NReRf, NHCORg, NHCONReRf and NHSO2Rg; Rc and Rd are independently selected from hydrogen, alkyl, alkenyl, alkynyl , alkoxy, NReRf, aryl, hydroxy, aryloxy, heteroaryl, cycloheteroalkyl, heteroarylalkyl, cycloheteroalkylalkyl, hydroxyaryl and aryloxyalkyl; Re and Rf each time they appear are the same or different and are independently selected from hydrogen, aryl, alkyl, alkenyl, alkynyl, alkoxy , amino, substituted amino, alkoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, heteroaryl, cycloheteroalkyl, heteroarylalkyl, cycloheteroalkylalkyl, cycloalkyl and cycloalkylalkyl, with the proviso that Re and Rf are not both alkoxy or amino; or Re and Rf each time they appear together the nitrogen to which they are attached to form a 5, 6 or 7-membered heteroaryl or cycloheteroalkyl ring containing 1, 2 or 3 heteroatoms that may be N, O or S; Rg each time it appears is selected from hydrogen, aryl, alkyl, alkenyl, alkynyl, alkoxy, amino, substituted amino, alkoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, heteroaryl, cycloheteroalkyl or, heteroarylalkyl, cycloheteroalkylalkyl, cycloalkyl and cycloalkylalkyl; Z is S (O) tNR1R2, CONR1R2 or CH2NR1R2, in which R1 and R2 are the same or different and are independently selected from hydrogen, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl aryl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloalkenyl, monoalkylaminoalkyl, dialkylaminoalkyl, cycloheteroalkylalkyl, hydroxyaryl, aryloxyalkyl, alkoxyalkyl or hydroxyalkyl, and in which t is 1 or 2; and rings A and B represent carbocyclic or heterocyclic, partially saturated or unsaturated rings of 6 members. |
| priorityDate | 2004-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 931.