| abstract |
Use of an inhibitor of a polypeptide having or comprising the amino acid sequence of SEQ IDNOs 18, 19, 20, 23 or 25 or of a polynucleotide encoding said polypeptide for the preparation of a pharmaceutical composition to prevent, alleviate or treat diseases or conditions associated with degeneration or injury of the nervous tissue of the vertebrate, associated with seizures, associated with angiogenic disorders other cardiovascular system disorders, wherein said inhibitor is an antibody or a Fab fragment, F (ab ') 2, Fv oscFv thereof, or an aptamer, all capable of binding to a polypeptide that has or comprises the amino acid sequence of SEQ ID NO: 18, 20, 23 or 25, or is a specific nucleic acid molecule that interacts with a polynucleotide encoding said polypeptide. |