| abstract |
A purified antibody, or a fragment or derivative thereof, wherein said antibody, or fragment or derivative thereof: - recognizes and binds to the CDR3 loop of an invariant T lymphocyte (TCR) antigen receptor, - (i) is binds and (ii) expands or activates at least one subpopulation of T lymphocytes selected from the group of: NK T lymphocytes, reactive T lymphocytes for CD1d and JαQ + T lymphocytes, and - does not recognize or bind substantially to other molecules; in which said derivative is an antibody or chemically modified antibody fragment, through gene fusion technology, or through chemical synthesis, so that it is covalently bound to a toxin, therapeutically active compound, enzyme, cytokine, radiolabeller, fluorescent label or affinity tag. |