| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5af24bfbb650ae2e7ddf95747271e81 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-98 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6842
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6851 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-25 |
| filingDate |
2006-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a433f2561ef273bc0413c27bfcf2a2b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f350a3ef6bc89b07b86e41db259844d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6b0566ff43a3f155ad977118ffb6600
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d798646569bb81f27ffe8a7c63b956f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5d39a2ce1d86f9b6986ff26ce267cfa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eee539c7d7c0de2fd4369bb69a377c76 |
| publicationDate |
2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2389111-T3 |
| titleOfInvention |
Mass spectrometry assays for acetyltransferase / deacetylase activity |
| abstract |
Method for identifying a compound that activates a sirtuin, comprising: contacting a set of peptide substrates with a sirtuin in the presence of a test compound, in which the concentration of the peptide substrate in the set of peptide substrates is below the Km of the sirtuin for the peptide substrate, and in which the members of said set of peptide substrates comprise at least one acetylated lysine residue, and determine the level of acetylation of the set of peptide substrates by mass spectrometry, in which a reduction in the level of acetylation of the set of peptide substrates in the presence of the problem compound, compared to a control reaction in which the test compound is not included, is indicative of a compound that activates a sirtuin |
| priorityDate |
2005-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |