| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1688
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-133
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate |
2004-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8503aa586859237e56eca417a89dee90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_def1364b319bde9b81dae23001f9334c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bca011e9dfbad7512fc64e567b66556a |
| publicationDate |
2012-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2388924-T3 |
| titleOfInvention |
Method for preparing submicron particles of paclitaxel or docetaxel |
| abstract |
Method for preparing a pharmaceutical composition of submicron particles of paclitaxel or docetaxel, the solubility of paclitaxel or docetaxel being greater in a first solvent miscible in water than in a second solvent that is aqueous, including the method the steps of: i) mixing a first modifier surface comprising a phospholipid conjugated with a water-soluble or hydrophilic polymer in the first water miscible solvent or in the second solvent or both, the first water miscible solvent and the second solvent; ii) mixing a second surface modifier selected from the group consisting of anionic, cationic, non-ionic and biological modifying agents with surface activity, in the first water-miscible solvent or in the second solvent or in both, the first water-miscible solvent and the second solvent; iii) dissolve paclitaxel or docetaxel in the first water miscible solvent to form a solution; iv) mixing the solution with the second solvent to define a pre-suspension of particles; and v) homogenize the pre-suspension to form a suspension of small particles with an average effective particle size of less than about 1,000 nm. |
| priorityDate |
2003-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |