| abstract |
A compound of Formula I, including pharmaceutically acceptable salts thereof, wherein: Q is then R2 is selected from the group consisting of hydrogen, halogen and methoxy; yR3 is hydrogen; or Q is: and R2 is halogen or hydrogen and R3 is hydrogen; R4 is B; B is selected from the group consisting of substituted phenyl, substituted heteroaryl and C (O) R7 in which said heteroaryl is optionally substituted and phenyl is substituted with one to three equal or different halogens or one to two equal substituents or different selected from the group F; F is selected from the group consisting of (C1-6) alkyl, cycloalkyl (C3-6), aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy (C1-6), thioalkoxy (C1-6 ), cyano, halogen, carbonyl, benzyl, -NR42C (O) -alkyl (C1-6), -NR42C (O) -cycloalkyl (C3-6), -NR42C (O) -aryl, -NR42C (O) - heteroaryl, -NR42C (O) -heteroalicyclic, a cyclic N-amido, -NR42S (O) 2-C 1-6 alkyl, -NR42S (O) 2-cycloalkyl (C3-6), -NR42S (O) 2 -aryl, -NR42S (O) 2-heteroaryl, -NR42S (O) 2-heteroalicyclic, -S (O) 2 NR42R43, NR42R43, (C1-6) alkyl C (O) NR42R43, C (O) NR42R43, NHC (O) NR42R43, OC (O) NR42R43, NHC (O) OR54, (C1-6) alkyl NR42R43, COOR54 and (C1-6) alkyl COOR54 wherein said (C1-6) alkyl cycloa (C3-6) alkyl, aryl, heteroaryl, heteroalicyclic, (C1-6) alkoxy, are optionally substituted with one to three odifferent equal halogens or one to two equal or different substituents selected from the group G; G is selected from the group consisting of (C1-6) alkyl, (C3-7) cycloalkyl, aryl, heteroaryl, heteroalicyclic, hydroxy, (C1-6) alkoxy, thioalkoxy (C1-6), thioaryloxy, cyano, halogen, nitro, carbonyl, thiocarbonyl, benzyl, -NR48 (O) -alkyl (C1-6), -NR48C (O) -cycloalkyl (C3-6), -NR48C (O) -aryl, -NR48C (O) -heteroaryl, -NR48C (O ) -heteroalicyclic, an N-amidocyclic, -NR48S (O) 2-alkyl (C1-6), -NR48S (O) 2-cycloalkyl (C3-6), -NR48S (O) 2-aryl, -NR48S (O ) 2-heteroaryl, -NR48S (O) 2-heteroalicyclic, sulfonyl, -S (O) 2 NR48R49, NR48R49, (C1-6) C (O) alkyl NR48R49, C (O) NR48R49, NHC (O) NR48R49, OC (O) NR48R49, NHC (O) OR54, (C1-6) alkyl NR48R49, COOR54 and (C1-6) alkyl COOR54; R1 is hydrogen; m is 2; R5 is hydrogen; R6 does not exist; R7 is selected from the grup or consisting of aryl, heteroaryl and heteroalicyclic, in which said aryl, heteroaryl and heteroalicyclic are optionally substituted with one to three same or different halogens or with two same or different substituents selected from the group F |