| abstract |
A compound represented by Formula (I): ** Formula ** in which: R1 is represented by Formula II: ** Formula ** X is O; Y and Z are C; R11 is 1-acyl-pyrrolidin-3-yl, 1-alkoxycarbonyl-pyrrolidin-3-yl, 1-amidino-pyrrolidin-3-yl, 1-sulfonyl-pyrrolidin-3-yl, 3- oxo-tetrahydro-pyrrolo [ 1,2-c] oxazol-6-yl, 1-acyl-piperidin-3-yl, 1-alkoxycarbonyl-piperidin-3-yl, 1-amidino-piperidin-3-yl, 1-sulfonyl-piperidin-3- ilo, which optionally has a substituent on the C1-C4 alkoxy or C1-C4 alkoxyalkyl, 1-acetyl-piperidin-3-yl, 1-methoxyacetyl-piperidin-3-yl, 1- (azetidine-1-carbonyl) - piperidin-3-yl, 1-methoxycarbonyl-piperidin-3-yl, 1- ethoxycarbonyl-piperidin-3-yl, 1-dimethylaminocarbonyl-piperidin-3-yl, 1-methanesulfonyl-piperidin-3-yl, 1- (ethane -2-sulfonyl) -piperidin-3-yl, 1- (propane-2-sulfonyl) -piperidin-3-yl, 1- (azetidin-1-yl-sulfonyl) -piperidin-3-yl, 1- dimethylamino- sulfonyl-piperidin-3-yl, 1- (N1-azetidin-1-yl-N2-cyano-amidino) -piperidin-3-yl, 1- (N2-cyano-N1, N1-dimethyiamidino) -piperidin-3- yl, 1-acetyl-pyrrolidin-3-yl, 1-methoxyacetyl-pyrrolidin-3-yl, 1- (azetidine-1-carbonyl) -pyrrolidin-3-yl, 1-methoxycar Bonyl-pyrrolidin-3-yl, 1-methoxycarbonyl-2-methoxymethyl-pyrrolidin-4-yl, 1-methanesulfonyl-pyrrolidin-3-yl, 1- (ethane-2-sulfonyl) -pyrrolidin-3-yl, 1- (ethane-2-sulfonyl) -4-methoxy-pyrrolidin-3-yl, 1- (ethane-2-sulfonyl) -5-methoxymethyl-pyrrolidin-3-yl, 1- (propane-2-sulfonyl) -pyrrolidine- 3-yl, 1- (azetidin-1-yl-sulfonyl) -pyrrolidin-3- yl, 1-dimethylaminosulfonyl-pyrrolidin-3-yl, 1-dimethylaminosulfonyl-2-methoxymethyl-pyrrolidin-4-yl, 1- (N1 -azetidin-1-yl- N2-cyano-amidino) -pyrrolidin-3-yl, 1- (N2-cyano-N1, N1-dimethiamidino) -pyrrolidin-3-yl or 1-oxo-tetrahydropyrrolo [-3- c ] oxazol-6-yl. R1.2 is hydrogen; R1.3 is fluorine; and R2 is isooxazol-3-yl, 5-methyl-isooxazol-3-yl, isooxazol-5-yl, pyrazol-3-yl, pyrazinyl, phenyl having one or two substituents selected from: C1-C5 alkyl, C1 alkoxy -C4, halo, hydroxy and C1-C5 hydroxyalkyl; pyridin-2-yl, pyridin-3-Ilo or pyridin-4-yl having, optionally, a substituent selected from: acetyl, C1-C5 alkyl, C1-C4 alkoxy, C1-C4 alkoxyalkyl, C1-C4 alkoxycarbonyl, carboxy and trifluoromethyl. or a single stereoisomer, mixtures of stereoisomers |