| abstract |
A compound of formula (1B), or a pharmaceutically acceptable salt or solvate thereof, ** Formula ** wherein: R1 represents H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C3 alkyl substituted by halogen or C1-C3 alkyl substituted by C3-C6 cycloalkyl; R2 represents C2-C6 alkyl, C3-C6 cycloalkyl, C1-C3 alkyl substituted by halogen or C1-C3 alkyl substituted by C3-C6 cycloalkyl; R3 represents C1-C6 alkyl, C3-C6 cycloalkyl, C1-C3 alkyl substituted by halogen, C1-C3 alkyl substituted by C1-C3 alkoxy or C1-C3 alkyl substituted by C3-C6 cycloalkyl; t> = 1-5; R6 represents C1-C6 alkyl, C3-C6 cycloalkyl, C1-C3 haloalkyl, C1-C3 alkoxy, phenyl, pyridyl, furanyl, pyridacinyl, pyrazinyl, imidazolyl, C1-C3 substituted with hydroxyl, alkoxy C1-C3, acetoxy, phenyl, pyridyl, furanyl, pyridacinyl, pyrimidinyl, pyrazinyl, imidazolyl; the above phenyl, pyridyl, furanyl, pyridacinyl, pyrimidinyl, pyrazinyl, imidazolyl optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy; R7 and R8 independently represent H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C3 haloalkyl, C1-C6 alkoxy; C1-C3 alkyl substituted with hydroxyl, acetoxyl, C1-C3 alkoxy, or R7 and R8 together with the nitrogen to which they are attached form a heterocyclic ring of four atoms to eight atoms, including morpholino, piperidine, pyrrole, piperazine; the above heterocyclic ring optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 haloalkyl, C1-C6 alkoxy. |