| abstract |
A fused pyrrocarbozole compound of Formula II: ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt thereof wherein: the A ring together with the carbon atoms to which it is attached, is a phenylene ring in which it they can replace 1 to 3 carbon atoms with nitrogen atoms: R1 is H or optionally substituted alkyl, wherein said substituents are one to three groups R10; R2 is selected from H, C (> = O) R2a, C (> = O) NR2CR2d, SO2R2b, CO2R2b, C1 8 optionally substituted alkyl, C28 optionally substituted alkenyl, C2 8 optionally substituted alkynyl, C3-10 optionally substituted heterocycloalkyl and optionally substituted cycloalkyl, wherein said optional substituents are one to three R10 groups; R2a is selected of C1-8 optionally substituted alkyl, C6-12 optionally substituted aryl, OR2bNR2cR2d, (CH2) pNR2cR2d, and O (CH2) pNR2cR2d, wherein said optional substituents are one to three groups R10; R2b is selected from H and optionally substituted C1 8 alkyl, wherein said optional substituents are one to three R10 groups; R2c and R2d are each independently selected from H and C1 8 optionally substituted alkyl, or together with the nitrogen to which they are attached form an optionally substituted heterocycloalkyl, wherein the aforementioned substituents are one to three R10 groups: at least one of R3, R4, R5, and R6 is selected from the group consisting of OR14; C (> = O) R22; CH> = NR26; NR11C (> = O) R20, NR11C (> = O) OR15; OC (> = O) R20, OC (> = O) NR11R20; O- (C1 8 alkylene) -R24; Z1- (C1 8alkylene) -R23, where Z1 is selected from CO2, O2C, C (> = O), NR11C (> = O), and NR11C (> = O) O; and (C1 8 alkylene) -Z2- (C1-8 alkylene) -R23, where Z2 is selected from O, S (O) and, C (> = O) NR11, NR11C (> = O), NR11C (> = O) NR11, OC (> = O) NR11 and NR11C (> = O) O. |